System and device for characterizing cells

US8934698B2 · kind B2 · utility

Assignees

• THE JOHNS HOPKINS UNIVERSITY · US
• University of Florida Foundation, Incorporated · US

Inventors

• Denis Wirtz · Washington, US
• Pei-Hsun Wu · Hsinchu, TW
• Shyam B. Khatau · Baltimore, US
• Wei-Chiang Chen · Baltimore, US
• Jude M. Phillip, Jr. · Baltimore, US
• Zev Binder · Baltimore, US
• Yiider Tseng · Gainesville, US

Key dates

• Filing date: Jun 22, 2012
• Grant date: Jan 13, 2015
• Expiry date: Oct 12, 2032

Classification

• Technology area (CPC G): Physics
• CPC primary: G06T2207/30024
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A diagnostic device includes a microscope configured to obtain image data on a plurality of cells and a computing device. The computing device is configured to receive the image data, identify at least a portion of each of the plurality of cells based on the received image data, determine at least one of a value of a morphological parameter for each identified at least a portion of the plurality of cells or a relative organization among the identified at least a portion of the plurality of cells, and calculate statistics for the plurality of cells based on the at least one of the determined values of the morphological parameter or the determined relative organization, the statistics including information suitable for distinguishing metastatic cells from non-metastatic cells. The diagnostic device further includes an output device configured to output the statistics for diagnosis.