Integrated sensor arrays for biological and chemical analysis
US8936763B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 22, 2009 |
| Grant date | Jan 20, 2015 |
| Priority date | — |
| Expiry date | Jul 18, 2030 |
Classification
- Technology area (CPC H)Electricity
- CPC primaryH10D84/01
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention is directed to apparatus and chips comprising a large scale chemical field effect transistor arrays that include an array of sample-retaining regions capable of retaining a chemical or biological sample from a sample fluid for analysis. In one aspect such transistor arrays have a pitch of 10 μm or less and each sample-retaining region is positioned on at least one chemical field effect transistor which is configured to generate at least one output signal related to a characteristic of a chemical or biological sample in such sample-retaining region. In one embodiment, the characteristic of said chemical or biological sample is a concentration of a charged species and wherein each of said chemical field effect transistors is an ion-sensitive field effect transistor having a floating gate with a dielectric layer on a surface thereof, the dielectric layer contacting said sample fluid and being capable of accumulating charge in proportion to a concentration of the charged species in said sample fluid. In one embodiment such charged species is a hydrogen ion such that the sensors measure changes in pH of the sample fluid in or adjacent to the sample-retaining region thereof…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.