Low density lipoprotein receptor-mediated siRNA delivery
US8937051B2 · kind B2 · utility
2Cited by
6References
16Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Sep 23, 2013 |
| Grant date | Jan 20, 2015 |
| Priority date | — |
| Expiry date | Sep 23, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/35
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides interfering RNA molecule-ligand conjugates useful as a delivery system for delivering interfering RNA molecules to a cell in vitro or in vivo. The conjugates comprise a ligand that can bind to a low density lipoprotein receptor (LDLR) or LDLR family member. Therapeutic uses for the conjugates are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.