17-hydroxy-19-nor-21-carboxylic acid-steroid γ-lactone derivative, use thereof, and medicament containing the derivative

US8937058B2 · kind B2 · utility

Inventors

• Ulrich Klar · Berlin, DE
• Joachim Kuhnke · Leverkusen, DE
• Rolf Bohlmann · Berlin, DE
• Jan Hübner · Berlin, DE
• Sven Ring · Jena, DE
• Thomas Frenzel · Berlin, DE
• Frederik Menges · Schriesheim, DE
• Steffen Borden · Berlin, DE
• Hans-Peter Muhn · Berlin, DE
• Katja Prelle · Berlin, DE

Key dates

• Filing date: Dec 23, 2008
• Grant date: Jan 20, 2015
• Expiry date: Feb 26, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J19/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to 17-hydroxy-19-nor-21-carboxylic acid-steroid γ-lactone derivatives with the chemical formula I, where R4, R6a, R6b, R7, R15, R16a, R16b, R18 and Z have the meanings stated in claim 1, and their solvates, hydrates, stereoisomers and salts. The invention further relates to the use of these derivatives for the production of a medicinal product for oral contraception and for the treatment of pre-, peri- and postmenopausal complaints and medicinal products that contain said derivatives. The derivatives according to the invention have a progestational and in preferred cases additionally an antimineralocorticoid and neutral to slightly androgenic action.