Manufacture of active highly phosphorylated human N-acetylgalactosamine-6-sulfatase and uses thereof
US8940513B2 · kind B2 · utility
2Cited by
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20Claims
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Key dates
| Filing date | May 19, 2014 |
| Grant date | Jan 27, 2015 |
| Priority date | — |
| Expiry date | May 19, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y301/06004
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention provides compositions of active highly phosphorylated human N-acetylgalactosamine-6-sulfatase (GALNS), and pharmaceutical compositions and formulations thereof, methods of producing and purifying GALNS, and its use in the diagnosis, prophylaxis, or treatment of diseases and conditions, including particularly lysosomal storage diseases that are caused by, or associated with, a deficiency in the GALNS enzyme, e.g., Mucopolysaccharidosis IVa (MPS IVa or Morquio A syndrome).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.