Purine compounds as prodrugs of A2B adenosine receptor antagonists, their process and medicinal applications

US8940751B2 · kind B2 · utility

Assignee

• Advinus Therapeutics Limited

Inventors

• Dinesh Barawkar · Lake Forest, US
• Sujay Basu · Mumbai, IN
• Vidya Ramdas · Pune, IN
• Venkata P. Palle · Mountain View, US
• Yogesh Waman · Pune, IN
• Meena Patel · Libertyville, US
• Anil Panmand · Pimpri-Chinchwad, IN

Key dates

• Filing date: Sep 9, 2011
• Grant date: Jan 27, 2015
• Expiry date: Sep 9, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/65616
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure relates to purine compounds of formula (I) or formula (II) or its tautomers, polymorphs, stereoisomers, solvates or a pharmaceutically acceptable salts, or pharmaceutical compositions containing them and methods of treating conditions and diseases that are mediated by thereof as A2B adenosine receptor antagonists.The compounds of the present disclosure are useful in the treatment, prevention or suppression of diseases and disorders that may be susceptible to improvement by the mediation of adenosine A2B receptor. The present disclosure also relates to methods for the preparation of such compounds, and to pharmaceutical compositions containing them.