Silicone hydrogel lens with a crosslinked hydrophilic coating

US8944592B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• Yongxing Qiu · Duluth, US
• Newton T. Samuel · Suwanee, US
• John Dallas Pruitt · Suwanee, US
• Chandana Kolluru · Suwanee, US
• Arturo Norberto Medina · Suwanee, US
• Lynn Cook Winterton · Roswell, US
• Daqing Wu · Suwanee, US
• Xinming Qian · Johns Creek, US
• Jared Nelson · Buford, US

Key dates

• Filing date: Jul 23, 2013
• Grant date: Feb 3, 2015
• Expiry date: Jul 23, 2033

Classification

• Technology area (CPC G): Physics
• CPC primary: G02C2202/16
• WIPO field: Basic materials chemistry
• WIPO sector: Chemistry

Abstract

The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.