Medical devices incorporating ceragenin-containing composites

US8945217B2 · kind B2 · utility

Assignees

• BRIGHAM YOUNG UNIVERSITY · US
• University of Utah Research Foundation · US

Inventors

• Paul B. Savage · Mapleton, US
• Roy D. Bloebaum · Salt Lake City, US
• Dustin Williams · Bountiful, US
• Kristofer D. Sinclair · Salt Lake City, US
• Bryan Haymond · Lost Acres, US

Key dates

• Filing date: Aug 24, 2012
• Grant date: Feb 3, 2015
• Expiry date: Dec 17, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2300/404
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

A medical device that includes a coating of a composite material that includes a polymeric material having a void structure and particulate ceragenin material (i.e., ceragenin particles) associated with the void structure. The average particle size of the ceragenin particles in the composite is in a range from 5 nm to 20 μm, 50 nm to 10 μm, 100 nm to 5 Ξm, or 1 μm to 10 μm. The composite has a high loading of ceragenin particles (e.g., about 10% to about 25%, by weight). The composite has good polymer stability, the ability to release ceragenins from the ceragenin particles disposed in the composite over a sustained period of time at a characteristic elution rate, and the ability to kill large numbers of bacteria and other susceptible microbes over the sustained period of time.