Implant for the repair of a cartilage defect and method for manufacturing the implant
US8945535B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 18, 2006 |
| Grant date | Feb 3, 2015 |
| Priority date | — |
| Expiry date | Aug 10, 2027 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L27/3852
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
For the repair of a cartilage defect in a human or animal patient use is made of an implant comprising an implant body including a natural cartilage matrix and being coated with cells having a chondrogenic potential. These cells are produced by in vitro cell proliferation starting from chondrocytes isolated from a cartilage biopsy. The chondrocytes which are de-differentiated during cell proliferation are re-differentiated during tissue culturing and are in particular suitable for producing and maintaining the cartilage matrix of the implant body. The cells adhering to the surface of the implant body are preferably also chondrocytes being de-differentiated by cell proliferation, but not re-differentiated, and are therefore particularly suitable for integrating the implant in the defect. Due to the cells adhering to the surface of the implant body, the implant is successfully integrated in the viable tissue surrounding the defect.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.