Patent · US Active

Antigen-specific clonal expansion of B cells

US8945923B2 · kind B2 · utility

2Cited by

0References

8Claims

0Family size

Assignees

BioNTech AG · DE
Universitätsmedizin der Johannes Gutenberg-Universität Mainz · DE

Inventors

Ugur Sahin · Mainz, DE
Ozlem Tureci · Homburg, DE
Torsten Seppmann · Mainz, DE
Holger Hoff · Mainz, DE
Jens Schumacher · Heidelberg, DE

Key dates

Filing date	Oct 29, 2010
Grant date	Feb 3, 2015
Priority date	—
Expiry date	Oct 29, 2030

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/30
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present invention provides recombinant proteins comprising the amino acid sequence of an intracellular segment of CD40 and an amino acid sequence mediating the association of the recombinant protein with the constant region of an immunoglobulin heavy chain. The recombinant proteins according to the present invention are useful for inducing clonal expansion of a B cell having a predetermined antigen-specificity without the need for T cell or CD40L mediated co-stimulation. Thus, the present invention provides tools for clonal expansion of B cells specific for an antigen of interest and the production of B cells secreting antibodies specific for an antigen of interest. The recombinant proteins of the present invention may also be used for generating fully human monoclonal antibodies with a predetermined antigen-specificity from the B cell repertoire of a human subject.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.