Agent for suppressing expression of dominant allele
US8946185B2 · kind B2 · utility
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9Claims
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Key dates
| Filing date | Jun 17, 2011 |
| Grant date | Feb 3, 2015 |
| Priority date | — |
| Expiry date | Jun 29, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/34
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An agent for selectively suppressing the expression of a dominant allele while allowing expression of wild-type or desired alleles and methods for using the agent are described. The RNAi agent has a structure obtained by assigning a dominant point mutation in the targeted allele as a standard point, setting a base length from the standard point to the 5′ end to a predetermined length, and introducing one mismatch base differing from the target sequence to a predetermined position downstream from the standard point.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.