Patent · US Active

Benzodioxane inhibitors of leukotriene production

US8946203B2 · kind B2 · utility

5Cited by

7References

16Claims

0Family size

Assignee

Boehringer Ingelheim International GmbH · DE

Inventors

Asitha Abeywardane · Danbury, US
Steven Richard Brunette · Ridgefield, US
Michael J. Burke · West Haven, US
Suresh R. Kapadia · Danbury, US
Thomas Martin Kirrane, Jr. · Danbury, US
Matthew Russell Netherton · Danbury, US
Hossein Razavi · Danbury, US
Sonia Rodriguez · Avon, US
Anjan Saha · Hamden, US
Robert Sibley · North Haven, US
Lana Louise Smith-Keenan · Poughquag, US
Hidenori Takahashi · Lagrangeville, US
Michael Robert Turner · Danbury, US
Jiang-Ping Wu · Lexington, US
Erick Richard Roush Young · Danbury, US
Qiang Zhang · Dalian, CN
Qing Zhang · Short Hills, US
Renee M. Zindell · New Milford, US

Key dates

Filing date	Mar 5, 2013
Grant date	Feb 3, 2015
Priority date	—
Expiry date	Mar 5, 2033

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D519/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to compounds of formula (I):wherein R1 to R3, A, X and n are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorder. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.