Annelated N-heterocyclic sulfonamides with oxadiazolone headgroup, processes for their preparation and their use as pharmaceuticals

US8946212B2 · kind B2 · utility

Assignee

• Sanofi-Aventis · FR

Inventors

• Stefanie Keil · Frankfurt am Main, DE
• Matthias Urmann · Eschborn, DE
• Wolfgang Wendler · Bad Camberg, DE
• Maike Glien · Frankfurt am Main, DE
• Hans Matter · Langenselbold, DE
• Eugen Falk · Frankfurt am Main, DE

Key dates

• Filing date: May 22, 2009
• Grant date: Feb 3, 2015
• Expiry date: Mar 23, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D498/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Annelated N-heterocyclic sulfonamides with oxadiazolone headgroup, processes for their preparation and their use as pharmaceuticals The invention relates to annelated N-heterocyclic sulfonamides with oxadiazolone headgroup and to their physiologically acceptable salts and physiologically functional derivatives showing PPARdelta or PPARdelta and PPARalpha agonist activity. What is described are compounds of the formula I, in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparations. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistance is involved and demyelinating and other neurodegenerative disorders of the central and peripheral nervous system.