Patent · US Active

Process for the preparation of lenalidomide

US8946265B2 · kind B2 · utility

5Cited by

4References

9Claims

0Family size

Assignee

Generics [UK] Limited · GB

Inventors

Vinayak Govind Gore · Panvel, IN
Vinay Kumar Shukla · Jamkhed, IN
Shreyas Bhandari · Jamkhed, IN
Suresh Hasbe · Jamkhed, IN

Key dates

Filing date	Mar 1, 2010
Grant date	Feb 3, 2015
Priority date	—
Expiry date	Jul 21, 2030

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P37/06
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to improved processes for preparing 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione (I) (lenalidomide) and its intermediate 3-(1-oxo-4-nitro-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione. The present invention further relates to improved processes for preparing lenalidomide crystalline form A, use of said crystalline form A as an active pharmaceutical ingredient or as an intermediate in the preparation of further crystalline or amorphous forms of lenalidomide, compositions comprising lenalidomide crystalline form A and their use in the treatment of disease.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.