Substituted triazole and imidazole derivatives as gamma secretase modulators

US8946266B2 · kind B2 · utility

Assignees

• Janssen Pharmaceuticals, Inc. · BE
• Cellzome Limited · GB

Inventors

• Tongfei Wu · Leuven, BE
• Henricus Jacobus Maria Gijsen · Breda, NL
• Frederik Jan Rita Rombouts · Wilrijk, BE
• François Paul Bischoff · Vosselaar, BE
• Didier Jean-Claude Berthelot · Edegem, BE
• Daniel Oehlrich · Brecht, BE
• Michel Anna Jozef De Cleyn · Merksplas, BE
• Serge Maria Aloysius Pieters · Wichelen, BE
• Garrett Berlond Minne · Bissegem, BE
• Adriana Ingrid Velter · Ravels, BE
• Sven Franciscus Anna Van Brandt · Nijlen, BE
• Michel Surkyn · Kessel-Lo, BE

Key dates

• Filing date: Jul 13, 2010
• Grant date: Feb 3, 2015
• Expiry date: Aug 4, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D498/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention is concerned with novel substituted triazole and imidazole derivatives of Formula (I)wherein R1, R2, A1, A2, A3, A4, X, and Het1 have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.