Process for the preparation of sufentanil base and related compounds
US8946433B2 · kind B2 · utility
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6References
14Claims
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Key dates
| Filing date | Sep 15, 2011 |
| Grant date | Feb 3, 2015 |
| Priority date | — |
| Expiry date | Apr 22, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D409/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present disclosure generally related to an improved process for the preparation of various piperidine derivatives. More particularly, the present disclosure related to an improved process for preparing sufentanil base (1) and related compounds, which advantageously utilizes more cost effective and/or less hazardous reagents, including a dispersion comprising between about 50% and about 70% by weight (based on the total weight of the dispersion) of an alkali metal hydride, such as sodium hydride, as well as eliminates the need for expensive and/or time consuming purification techniques.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.