Patent · US Active

Process for the preparation of 2-hydroxy-4-phenyl-3,4-dihydro-2H-chromen-6-yl-methanol and (R)-feso-deacyl

US8946456B2 · kind B2 · utility

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1References

12Claims

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Assignee

CHEMI S.P.A. · IT

Inventors

Umberto Ciambecchini · Roma, IT
Stefano Turchetta · Roma, IT
Lorenzo De Ferra · Patrica, IT
Maurizio Zenoni · Paullo, IT

Key dates

Filing date	Apr 29, 2011
Grant date	Feb 3, 2015
Priority date	—
Expiry date	Apr 29, 2031

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07C215/54
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention regards an improved and industrially advantageous process for the preparation of the 2-hydroxy-4-phenyl-3,4-dihydro-2H-chromen-6-yl-methanol intermediates, also called “feso chromenyl” and (R)-2-[3-(diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)phenol, also called “(R)-feso deacyl”, which are in turn used in the synthesis of fesoterodine and in particular of fesoterodine fumarate. This process utilises reagents which are non-toxic and manageable at industrial level and enables obtaining a new stable and non-hygroscopic crystalline form of the key intermediate “(R)-feso deacyl”, called form B.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.