Patent · US Active

Prion-like form of CPEB and related compositions and methods

US8951734B2 · kind B2 · utility

0Cited by

0References

15Claims

0Family size

Assignee

The Trustees of Columbia University in the City of New York · US

Inventors

Kausik Si · Kansas City, US
Eric R. Kandel · Yonkers, US

Key dates

Filing date	Nov 5, 2004
Grant date	Feb 10, 2015
Priority date	—
Expiry date	Jul 15, 2030

Classification

Technology area (CPC G)Physics
CPC primaryG01N2333/395
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present invention provides methods for determining whether an agent facilitates the conversion of a cytoplasmic polyadenylation element binding (CPEB) protein from its non-prion form to its prion form. This invention also provides methods for determining the presence and amount of the prion form of CPEB protein in a cell. This invention also provides methods for facilitating the conversion of a non-prion CPEB protein to its prion form. This invention also provides an isolated prion form cytoplasmic polyadenylation element binding (CPEB) protein and compositions comprising a therapeutically effective amount of an agent that facilitates the conversion of CPEB protein from its non-prion form to its prion form, and methods of making such compositions.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.