Patent · US Active

Detection of shed CD31, diagnosis of atherothrombosis and autoimmune disorders, and methods for analyzing signaling pathways

US8951743B2 · kind B2 · utility

1Cited by

1References

9Claims

0Family size

Assignee

Institut National de la Sante et de la Recherche Medicale (INSERM) · FR

Inventors

Giuseppina Caligiuri · Paris, FR
Antonino Nicoletti · Paris, FR

Key dates

Filing date	Jun 30, 2009
Grant date	Feb 10, 2015
Priority date	—
Expiry date	May 9, 2031

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY10S435/973
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

The present invention stems from the finding that the extracellular domain of CD31 proteins present on blood leukocytes is shed and released in the circulation as a soluble form of CD31. A method for detecting shed CD31 is further disclosed. The invention therefore relates to a method for detecting a shed ectodomain of a transmembrane protein such as CD31 and to the use of such a method as a diagnostic tool. The invention further provides methods for determining whether a candidate protein is part of a molecular complex.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.