Mammalian artificial chromosome vector comprising human cytochrome P450 gene (cluster) and non-human mammalian animal retaining the same
US8951789B2 · kind B2 · utility
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1Claims
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Key dates
| Filing date | Oct 14, 2008 |
| Grant date | Feb 10, 2015 |
| Priority date | — |
| Expiry date | May 21, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2800/208
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
This invention relates to a mammalian artificial chromosome vector, which retains a human chromosome 7 fragment comprising human cytochrome P450 genes and is transmittable to progeny, wherein the human chromosome 7 fragment retains a region of approximately 1 Mb±500 Kb in size comprising at least a human CYP3A gene cluster, which region is located between chromosome markers AC004922 and AC073842, and to a non-human mammalian animal retaining the vector.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.