Generation of cardiomyocytes from human pluripotent stem cells
US8951798B2 · kind B2 · utility
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Key dates
| Filing date | Oct 12, 2012 |
| Grant date | Feb 10, 2015 |
| Priority date | — |
| Expiry date | Oct 12, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2506/45
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Methods for generating high-yield, high-purity cardiomyocyte progenitors or cardiomyocytes from pluripotent cells are described. Wnt/β-catenin signaling is first activated in pluripotent cells, e.g., by inhibition of Gsk-3 to obtain a first population of cells. Wnt/β-catenin signaling is then inhibited in the first cell population to induce cardiogenesis under fully defined, growth factor free culture conditions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.