Patent · US Active

Composition and method for enabling proliferation of pluripotent stem cells

US8951799B2 · kind B2 · utility

2Cited by

0References

18Claims

0Family size

Assignee

BioLamina AB · SE

Inventors

Anna Domogatskaya · Hakunge Säteri, SE
Sergey Rodin · Stockholm, SE
Karl Tryggvason · Stockholm, SE

Key dates

Filing date	Aug 25, 2009
Grant date	Feb 10, 2015
Priority date	—
Expiry date	Oct 1, 2030

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2533/52
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present disclosure is directed to the development of compositions, such as extracellular matrices, and processes for using the same, that both maintain stem cells in vitro pluripotency and enable self-renewal. In this regard, it has been discovered that when pluripotent mouse and human embryonic stem cells are cultured on plates coated with recombinant laminin-10 (laminin-511) or their functional domains, in the absence of differentiation inhibitors or feeder cells, the embryonic stem cells proliferated and maintained their pluripotency.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.