Glucagon-like peptide-1 analogues and uses thereof

US8951959B2 · kind B2 · utility

Assignee

• Betta Pharmaceuticals Co., Ltd · CN

Inventors

• Yinxiang Wang · Beijing, CN
• Fenlai Tan · Beijing, CN
• Shaojing Hu · Beijing, CN
• Xiangdong Zhao · Beijing, CN
• Cunbo Ma · Beijing, CN
• Yanping Wang · Beijing, CN
• Xiaoyan Shen · Beijing, CN
• Lieming DING · Zhejiang, CN
• Yunyan Hu · Beijing, CN
• Hong Cao · Beijing, CN
• Wei Long · Beijing, CN

Key dates

• Filing date: Apr 29, 2011
• Grant date: Feb 10, 2015
• Expiry date: Apr 29, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided is a glucagon-like peptide-1 (GLP-1) analog shown as the following formula, wherein X is selected from glycine and glycinamide. The GLP-1 analog has a non-proteogenic amino acid residue in position 8 relative to the sequence GLP-1, and is acylated with a moiety comprising two acidic groups to the lysine residue in position 26. The GLP-1 analog is resistant to dipeptidyl peptidase IV so as to have an extended half-life in vivo. Also provided is a use of the GLP-1 analog in conquering blood sugar.