Compositions comprising variants and fusions of FGF19 polypeptides, and uses and methods thereof for treatment of metabolic disorders and diseases
US8951966B2 · kind B2 · utility
55Cited by
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46Claims
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Key dates
| Filing date | Jun 29, 2012 |
| Grant date | Feb 10, 2015 |
| Priority date | — |
| Expiry date | Jun 29, 2032 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/66
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to variants and fusions of fibroblast growth factor 19 (FGF19), variants and fusions of fibroblast growth factor 21 (FGF21), fusions of fibroblast growth factor 19 (FGF19) and/or fibroblast growth factor 21 (FGF21), and variants or fusions of fibroblast growth factor 19 (FGF19) and/or fibroblast growth factor 21 (FGF21) proteins and peptide sequences (and peptidomimetics), having one or more activities, such as glucose lowering activity, and methods for and uses in treatment of hyperglycemia and other disorders.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.