Compounds

US8951999B2 · kind B2 · utility

Assignee

• OREXO AB · SE

Inventors

• Henning Priepke · Warthausen, DE
• Henri Doods · Warthausen, DE
• Raimund Kuelzer · Mittelbiberach, DE
• Roland Pfau · Biberach, DE
• Dirk Stenkamp · Biberach, DE
• Robert Roenn · Uppsala, SE
• Benjamin Pelcman · Stockholm, SE

Key dates

• Filing date: Oct 20, 2010
• Grant date: Feb 10, 2015
• Expiry date: Aug 15, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention relates to compounds of formula I,their use as inhibitors of the microsomal prostaglandin E2 synthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions such as inflammatory/nociceptive pain.A, M, R1, R2, R7, Ra, Rb, Q3, Q4, Q6, Z2, Z4, Z5, Z6 and W have meanings given in the description.