Amino- and amido-aminotetralin derivatives and related compounds as mu opioid receptor antagonists
US8952031B2 · kind B2 · utility
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5Claims
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Key dates
| Filing date | Mar 5, 2012 |
| Grant date | Feb 10, 2015 |
| Priority date | — |
| Expiry date | Jan 16, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2602/10
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention provides amino- and amido-aminotetralin compounds of formula (I):wherein R1, R2, R3, R4, R5, R6, R7, and n are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are antagonists at the mu opioid receptor. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat conditions associated with mu opioid receptor activity, and processes and intermediates useful for preparing such compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.