Heteroaryloxycarbocyclyl compounds as PDE10 inhibitors

US8952037B2 · kind B2 · utility

Assignee

• AMGEN INC. · US

Inventors

• Jennifer R. Allen · Newbury Park, US
• Michael J. Frohn · Thousand Oaks, US
• Paul E. Harrington · Camarillo, US
• Essa Hu · Camarillo, US
• Alexander J. Pickrell · Westlake Village, US
• Robert M. Rzasa · Ventura, US
• Kelvin Sham · Thousand Oaks, US

Key dates

• Filing date: May 11, 2011
• Grant date: Feb 10, 2015
• Expiry date: Dec 14, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Heteroaryloxycarbocyclyl compounds, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, Huntington's Disease, bipolar disorder, obsessive-compulsive disorder, and the like.