Phosphorylated and branched dihydroxy-pentane-dione (DPD) analogs as quorum sensing inhibitors in bacteria
US8952192B2 · kind B2 · utility
2Cited by
3References
8Claims
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Key dates
| Filing date | Mar 26, 2012 |
| Grant date | Feb 10, 2015 |
| Priority date | — |
| Expiry date | Jul 4, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/3808
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Provided are compositions and methods for modulating quorum sensing in microbes. The compounds are AI-2 analogs and as such have structures similar to 4,5-dihydroxy-2,3-pentanedione that can act as agonists/antagonists of quorum sensing. The compounds are useful for modulating quorum sensing in bacteria and can be used in methods for prophylaxis or therapy of bacterial infections and for reduction of biofilms.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.