Processes for the preparation of 5-HT2C receptor agonists

US8952197B2 · kind B2 · utility

Assignee

• Arena Pharmaceuticals, Inc. · US

Inventors

• John DeMattei · San Diego, US
• Carlos Marlon · Chula Vista, US
• Ryan O. Castro · San Diego, US
• Tsung-Hsun Chuang · Longmont, US
• Mark Allen Hadd · San Diego, US
• Xiao-Xiong Lu · San Diego, US
• Mark Macias · San Diego, US
• Stephen M. Shaw · London, GB

Key dates

• Filing date: Jun 17, 2010
• Grant date: Feb 10, 2015
• Expiry date: Jun 20, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C213/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to processes and intermediates useful in the preparation of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine (lorcaserin), a serotonin (5-HT) receptor modulator that is useful in the treatment of for example, central nervous system disorders, such as obesity.