Method for principal frequency magnetic resonance elastography inversion

US8952693B2 · kind B2 · utility

Assignee

• Mayo Foundation for Medical Education and Research · US

Inventors

• David S. Lake · Rochester, US
• Kiaran P. McGee · Rochester, US
• Armando Manduca · Rochester, US
• Yogesh K. Mariappan · Rochester, US
• Richard L. Ehman · Rochester, US

Key dates

• Filing date: Apr 23, 2012
• Grant date: Feb 10, 2015
• Expiry date: Sep 7, 2033

Classification

• Technology area (CPC G): Physics
• CPC primary: G01R33/56358
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A method for calculating a mechanical property of a material using a magnetic resonance imaging (“MRI”) system is provided. The method is particularly robust to image data having low signal-to-noise ratio (“SNR”). An MRI system is used to acquire magnetic resonance elastography (“MRE”) data from a subject containing the material. Exemplary materials include lung tissue. Images are reconstructed from the MRE data and used to produce a wave image from which a spatial frequency spectrum is produced. A principal frequency of the spatial frequency spectrum is produced and used to calculate a mechanical property of the material. For example, shear stiffness may be calculated.