Patent · US Active

Induced pluripotent stem cells produced with a connexin inhibitor and a TGF-β signaling inhibitor

US8956868B2 · kind B2 · utility

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11Claims
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Inventors

Key dates

Filing dateDec 27, 2011
Grant dateFeb 17, 2015
Priority date—
Expiry dateOct 5, 2032

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12N2506/45
  • WIPO fieldBiotechnology
  • WIPO sectorChemistry

Abstract

The present invention provides a method for producing iPS cells, comprising reacting cells with at least one connexin inhibitor and at least one TGFβ signaling inhibitor; iPS cells comprising at least one connexin inhibitor; an iPS cell inducer comprising at least one inhibitor selected from the group consisting of connexin inhibitors and TGFβ signaling inhibitors; a medium for inducing iPS cells, comprising at least one inhibitor selected from the group consisting of connexin inhibitors and TGFβ signaling inhibitors; and a kit for inducing iPS cells, comprising at least one inhibitor selected from the group consisting of connexin inhibitors and TGFβ signaling inhibitors.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.