Patent · US Active

Beta-catenin targeting peptides and uses thereof

US8957026B2 · kind B2 · utility

39Cited by

67References

21Claims

0Family size

Assignee

President and Fellows of Harvard College · US

Inventors

Gregory L. Verdine · Boston, US
Tom N. Grossmann · Dortmund, DE
Tsung-Han Johannes Yeh · Brookline, US

Key dates

Filing date	Sep 22, 2011
Grant date	Feb 17, 2015
Priority date	—
Expiry date	Sep 22, 2031

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K38/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention relates to β-catenin targeting peptides comprising an α-helical segment that are optionally stapled or stitched, and pharmaceutical compositions thereof. Uses of the inventive β-catenin targeting polypeptides including methods for treatment of disease, such as diseases associated with aberrant Wnt signaling, including cancer, are also provided.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.