Methods for preventing or treating mitochondrial permeability transition

US8957030B2 · kind B2 · utility

Assignees

• Cornell Research Foundation, Inc. · US
• Institut De Recherches Cliniques De Montreal · CA

Inventors

• Hazel H. Szeto · New York, US
• Peter W. Schiller · Montréal, CA
• Kesheng Zhao · New York, US

Key dates

• Filing date: Feb 27, 2013
• Grant date: Feb 17, 2015
• Expiry date: Feb 27, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K5/1024
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides a method of reducing or preventing mitochondrial permeability transitioning. The method comprises administering an effective amount of an aromatic-cationic peptide having at least one net positive charge; a minimum of four amino acids; a maximum of about twenty amino acids; a relationship between the minimum number of net positive charges (pm) and the total number of amino acid residues (r) wherein 3pm is the largest number that is less than or equal to r+1; and a relationship between the minimum number of aromatic groups (a) and the total number of net positive charges (pt) wherein 2 a is the largest number that is less than or equal to pt+1, except that when a is 1, pt may also be 1.