Processes and intermediates in the preparation of morphine analogs via N-demethylation of N-oxides using cyclodehydration reagents
US8957072B2 · kind B2 · utility
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Key dates
| Filing date | May 2, 2012 |
| Grant date | Feb 17, 2015 |
| Priority date | — |
| Expiry date | Jun 29, 2033 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A high-yielding method for the N-demethylation of oxycodone- and oxymorphone-N-oxides by the reaction of these compounds with cyclodehydration reagents has been performed. This method has been utilized to improve the synthesis of various morphine analogs, such as naltrexone, nalbuphone and naloxone.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.