Conjugated 3-(indolyl)- and 3-(azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment

US8957103B2 · kind B2 · utility

Assignee

• Johannes Gutenberg-Universität Mainz · DE

Inventors

• Gerd Dannhardt · Mainz, DE
• Stanislav Plutizki · Mainz, DE
• Christopher Ganser · Mainz, DE
• Eva Lauermann · Mainz, DE

Key dates

• Filing date: Dec 15, 2011
• Grant date: Feb 17, 2015
• Expiry date: Dec 15, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to 3-(Indolyl)- and 3-(azaindolyl)-4-phenylmaleimide compounds of formula (I) wherein R1, R2 and R3 are as defined in the description, and the physiologically acceptable salts, solvates and solvates of the salts of the compounds of formula (I). The compounds of formula (I) are suitable for treating tumors.