Patent · US Active

Recombinant protein for intracellular delivery of siRNA and composition comprising the same

US8957186B2 · kind B2 · utility

1Cited by

2References

10Claims

0Family size

Assignee

KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY · KR

Inventors

Hyung Jun Ahn · Daejeon, KR
Ick Chan Kwon · Seoul, KR
Kui-Won Choi · Seoul, KR

Key dates

Filing date	Dec 7, 2011
Grant date	Feb 17, 2015
Priority date	—
Expiry date	Nov 28, 2032

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/85
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to a recombinant protein for siRNA delivery, which allows the efficient intracellular and in vivo delivery of siRNA. More particularly, the present invention relates to a recombinant protein that allows a siRNA binding protein to be located in the interior cavity of a capsid protein of HBV (Hepatitis B virus), in which siRNAs of interest bind to the siRNA binding protein to be encapsulated within the capsid shell, thereby providing stability against the external attack such as nucleases and achieving the efficient intracellular and in vivo delivery of siRNA by its release into the cytosolic space after cell uptake.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.