Heteroaryl substituted benzothiazoles

US8957215B2 · kind B2 · utility

Assignee

• Navidea Biopharmaceuticals, Inc. · US

Inventors

• Ylva Gravenfors · Gately Drive, SE
• Catrin Jonasson · Gately Drive, SE
• Jonas Malmstrom · Gately Drive, SE
• Gunnar Nordvall · Gately Drive, SE
• David Pyring · Gately Drive, SE
• Can Slivo · Malung, SE
• Daniel Sohn · Gately Drive, SE
• Peter Strom · Gately Drive, SE
• David Wensbo · Malung, SE

Key dates

• Filing date: Apr 23, 2012
• Grant date: Feb 17, 2015
• Expiry date: Apr 23, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to novel heteroaryl substituted benzothiazole derivatives, precursors thereof, and therapeutic uses for such compounds, having the structural formula (I) below:and to their pharmaceutically acceptable salt, compositions and methods of use. Furthermore, the invention relates to novel heteroaryl substituted benzothiazole derivatives that are suitable for imaging amyloid deposits in living patients, their compositions, methods of use and processes to make such compounds. More specifically, the present invention relates to a method of imaging amyloid deposits in brain in vivo to allow antemortem diagnosis of Alzheimer's disease as well as measuring clinical efficacy of Alzheimer's disease therapeutic agents.