Ligand and metal complex having the same
US8961928B2 · kind B2 · utility
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15Claims
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Key dates
| Filing date | May 9, 2012 |
| Grant date | Feb 24, 2015 |
| Priority date | — |
| Expiry date | Jul 21, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N9/6491
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A ligand and a metal complex having the ligand are provided. The ligand and a paramagnetic metal ion form a metal complex with high stability, high relaxivity and high biocompatibility. The metal complex of the present invention is applicable to the preparation of MRI contrast agents for detecting atherosclerosis. The MRI contrast agent includes a peptide sequence specific to a matrix metalloprotease, and can be recognized by a pathological thrombocyte to target a specific site, so as to enhance the imaging contrast.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.