Polymer-metal complex composite having MRI contrast ability and MRI contrasting and/or antitumor composition using the same
US8961949B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 26, 2009 |
| Grant date | Feb 24, 2015 |
| Priority date | — |
| Expiry date | Jan 8, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08G83/001
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a polymer-metal complex composite, which comprises a block copolymer capable of serving as a constituent member of a polymeric micelle and a metal complex having MRI contrast ability, accumulates in a tumor-specific manner, achieves high image contrast even in a small amount, and has reduced side effects and a long retention time in blood.The polymer-metal complex composite of the present invention comprises a block copolymer (A) represented by general formula (a) and a metal complex (B) having MRI contrast ability, wherein the composite comprises a structure in which a carboxyl anion of poly(carbo) in the copolymer (A) is attached to the metal complex (B) via a metal atom (M).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.