Multi-layered transdermal system with triazine UV absorber

US8962013B2 · kind B2 · utility

Assignee

• Bayer Intellectual Property GmbH · DE

Inventors

• Thomas Langguth · Jena, DE
• Stefan Bracht · Hohen Neuendorf, DE

Key dates

• Filing date: May 2, 2006
• Grant date: Feb 24, 2015
• Expiry date: Jun 19, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/22
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The UV-stable solid transdermal therapeutic system (TTS) with UV absorber for photosensitive active pharmaceutical ingredients has a backing layer (1), at least one active ingredient-containing matrix (2), and a detachable protective film (3). Optionally an adhesive layer (4) and a separating layer (5) are introduced between the backing layer (1) and the at least one active ingredient-containing matrix (2). At least one hydroxyphenyltriazine compound acting as UV absorber is embedded in the backing layer (1), in the active ingredient-containing matrix (2), or in the adhesive layer (4). The TTS according to the invention achieves high stability at low concentrations of UV absorber, preferably 0.5 to 3% (m/m), so as to reduce or avoid skin irritation.