Epigenetic biomarker ADAMTS9 for diagnosis and prognosis of gastric cancer
US8962236B2 · kind B2 · utility
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7Claims
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Key dates
| Filing date | Mar 12, 2013 |
| Grant date | Feb 24, 2015 |
| Priority date | — |
| Expiry date | Mar 12, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y304/21075
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention provides a method for diagnosing and determining prognosis of gastric cancer in a subject by detecting suppressed expression of the ADAMTS9 gene, which in some cases is due to elevated methylation level in the genomic sequence of this gene. A kit and device useful for such a method are also provided. In addition, the present invention provides a method for treating gastric cancer by increasing ADAMTS9 gene expression or activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.