Triggered molecular geometry based bioimaging probes
US8962241B2 · kind B2 · utility
17Cited by
38References
24Claims
0Family size
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Key dates
| Filing date | Jul 19, 2011 |
| Grant date | Feb 24, 2015 |
| Priority date | — |
| Expiry date | Oct 11, 2032 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2021/6441
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present embodiments relate to engineering imaging probes based on “triggered molecular geometry.” Upon detection of a molecular signal, nucleic acid hairpin monomers assemble an imageable molecular shape with prescribed geometry. In some embodiments the prescribed shape can be imaged directly. In some embodiments, the prescribed shape can serve as a spatial organizer or amplification scheme for other imaging entities, such as fluorophore and fluorescent proteins.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.