Patent · US Active

Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses

US8962247B2 · kind B2 · utility

7Cited by

126References

16Claims

0Family size

Assignee

Sequenom, Inc. · US

Inventors

Mathias Ehrich · San Diego, US
Anders Olof Herman Nygren · San Diego, US
Taylor Jacob Jensen · San Diego, US

Key dates

Filing date	Mar 18, 2010
Grant date	Feb 24, 2015
Priority date	—
Expiry date	Feb 26, 2032

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Q2600/16
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Provided are compositions and processes that utilize genomic regions that are differentially methylated between a mother and her fetus to separate, isolate or enrich fetal nucleic acid from a maternal sample. The compositions and processes described herein are particularly useful for non-invasive prenatal diagnostics, including the detection of chromosomal aneuplodies.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.