Patent · US Active

Four-gene pathway for wax ester synthesis

US8962299B2 · kind B2 · utility

2Cited by
11References
33Claims
0Family size

Assignee

Inventors

Key dates

Filing dateFeb 29, 2012
Grant dateFeb 24, 2015
Priority date—
Expiry dateFeb 29, 2032

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12N9/16
  • WIPO fieldBiotechnology
  • WIPO sectorChemistry

Abstract

The invention relates to methods for producing a wax ester in recombinant host cells engineered to express a thioesterase, an acyl-CoA synthetase, an alcohol-forming fatty acyl reductase, and a wax ester synthase. The methods of the invention may take place in photosynthetic microorganisms, and particularly in cyanobacteria. Isolated nucleotide molecules and vectors expressing the thioesterase, acyl-CoA synthetase, alcohol-forming fatty acyl reductase, and wax ester synthase, recombinant host cells expressing the thioesterase, acyl-CoA synthetase, alcohol-forming fatty acyl reductase, and wax ester synthase, and systems for producing a wax ester via a pathway using these four enzymes, are also provided.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.