Inhibitors of glutaminyl cyclase

US8962860B2 · kind B2 · utility

Assignee

• PROBIODRUG AG · DE

Inventors

• Ulrich Heiser · Halle (Saale), DE
• Robert Sommer · Halle (Saale), DE
• Ulf-Torsten Gaertner · Halle (Saale), DE
• Antje Hamann · Schkopau, DE
• Michael Almstetter · Martinsried, DE
• Michael Thormann · Martinsried, DE
• Andreas Treml · Martinsried, DE
• Hans-Ulrich Demuth · Halle (Saale), DE
• Torsten Hoffman · Halle (Saale), DE

Key dates

• Filing date: Sep 4, 2009
• Grant date: Feb 24, 2015
• Expiry date: Jul 13, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of general formula (I):wherein R1, R2, R3, R4, X and Y are as defined herein are inhibitors of glutaminyl cyclase and are therefore useful in treating conditions that can be treated by modulation of glutaminyl cyclase activity.