Amorphous asiatic tromethamine salt and preparation method thereof

US8962880B2 · kind B2 · utility

Assignee

• SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY · CN

Inventors

• Guobin Ren · Shanghai, CN
• Ying Liu · Hsinchu, TW
• Jinyao Chen · Shanghai, CN
• Xiaoling Huang · Shanghai, CN
• Lin Xiao · Shanghai, CN
• Li Cai · Shanghai, CN
• Zhen Zhang · Shanghai, CN
• Xuejun Wu · Shanghai, CN
• Haiyan Sun · 安丰镇, CN
• Quanhai Liu · Shanghai, CN
• Liling Jin · Shanghai, CN
• Minyu Liu · Shanghai, CN
• Yifang Deng · Shanghai, CN
• Zhiru Xu · Shanghai, CN
• Renhai Chen · Shanghai, CN
• Chungang Li · Shanghai, CN
• Xiangduan Tan · Shanghai, CN
• Yan Qin · Hubei, CN

Key dates

• Filing date: Mar 21, 2012
• Grant date: Feb 24, 2015
• Expiry date: Mar 21, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J63/008
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

An amorphous asiatic tromethamine salt and the preparation method thereof. The method includes the steps of: (1) dissolving asiatic acid in an organic solvent; step (2) mixing with tromethamine; step (3) stirring and salifying the same, and then removing the organic solvent. The method for preparing the amorphous asiatic tromethamine salt is easy and effective, and the water solubility and bioavailability of the asiatic tromethamine salt thus obtained are greatly compared with the prior art.