Optimization of nucleation and crystallization for lyophilization using gap freezing

US8966782B2 · kind B2 · utility

Assignees

• Baxter International Inc. · US
• Baxter Healthcare SA · CH

Inventors

• Wei-Youh Kuu · Libertyville, US
• Mark Doty · Grayslake, US
• William S. Hurst · Burlington, US
• Christine L. Rebbeck · Lake Barrington, US

Key dates

• Filing date: Mar 28, 2012
• Grant date: Mar 3, 2015
• Expiry date: Jun 7, 2033

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N21/68
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

This application discloses devices, articles, and methods useful for producing lyophilized cakes of solutes. The devices and articles provide for a method of freezing liquid solutions of the solute by the top and the bottom of the solution simultaneously and at approximately the same rate. The as frozen solution can then provide a lyophilized cake of the solutes with large and uniform pores.