Method for assay on the effect of vascularization inhibitor
US8969344B2 · kind B2 · utility
1Cited by
69References
4Claims
0Family size
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Key dates
| Filing date | Sep 21, 2012 |
| Grant date | Mar 3, 2015 |
| Priority date | — |
| Expiry date | Dec 3, 2032 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/515
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a method of predicting the antitumor effect of an angiogenesis inhibitor. It is possible to predict the antitumor effect of an angiogenesis inhibitor by evaluating the EOF dependency of a tumor cell for proliferation and/or survival and using the EGF dependency as an indicator. Since the antitumor effect of an angiogenesis inhibitor correlates with the EGF dependency of a tumor cell for proliferation and/or survival, the angiogenesis inhibitors is capable of producing excellent antitumor effect when combined with a substance having EGF inhibitory activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.