Crystalline, anhydrous forms of oxymorphone hydrochloride

US8969368B2 · kind B2 · utility

Assignee

• GRÜNENTHAL GMBH · DE

Inventors

• Andreas Fischer · Castro Valley, US
• Dagmar Peters-Groth · Aachen, DE
• Dagmar Lischke · Eschweiler, DE

Key dates

• Filing date: Nov 27, 2013
• Grant date: Mar 3, 2015
• Expiry date: Nov 27, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Crystalline, anhydrous hydrochloride salts of 4,5α-epoxy-3,14-dihydroxy-17-methylmorphinan-6-one (oxymorphone) are disclosed and three polymorphic forms of these salts are reported. The invention further relates to a method for the production of such salts, a pharmaceutical composition comprising an effective amount of such a salt and such a salt as a medicament and for the treatment and/or prevention of pain.