Substituted 6-methylnicotinamides as mGluR5 positive allosteric modulators

US8969389B2 · kind B2 · utility

Assignee

• VANDERBILT UNIVERSITY · US

Inventors

• P. Jeffrey Conn · Brentwood, US
• Craig W. Lindsley · Brentwood, US
• Shaun R. Stauffer · Brentwood, US
• Ya Zhou · Nashville, US
• Jason Manka · Nashville, US
• Gregor McDonald · Beerse, BE
• José Manuel Bartolomé-Nebreda · Toledo, ES

Key dates

• Filing date: May 24, 2011
• Grant date: Mar 3, 2015
• Expiry date: May 24, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

In one aspect, the invention relates to substituted 6-methylnicotinamide analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.